4th Symposium on
Immunomodulation
in Cancer & Regeneration
Programme
23 JUNE 2023
09.00-09.15 Welcome
09.15-10.00 CAFfeinated tumors: lessons learned in paracrine biology using 3D model
Olivier de Wever, Laboratory of Experimental Cancer Research, CRIG- Cancer Research Institute Ghent, Ghent University, Belgium
10.00-10.30 Selected Oral Presentations
Deciphering the importance of the immune system in PDAC metastasis development
Inês Batista, i3S/IPATIMUP
Antibody blockade of the PSGL-1 checkpoint regulator promotes human T cell responses against lymphoma cells
João Luís Pereira, i3S/IPATIMUP
Unravel the role of KRAS/Galectin-3 axis in the interplay between Tumor-associated macrophages and colorectal cancer cells
Flávia Pereira, i3S/INEB /CBMA
10.30-11.00 Speed talks
FOXP3+-immune cells are an independent positive prognostic factor in colorectal cancer, depending on macrophage profile, tumor stage and anatomical location
Ana Manuela Borges, i3S
HLA-DR-expressing Cytotoxic T lymphocytes as a novel approach to improve Breast Cancer therapy
Rute Salvador, CEDOC, NOVA Medical School
Exploring new subsets of immunosuppressive neutrophils – targets to improve therapeutic strategies for metastatic breast cancer
Bruna Correia, CEDOC – NOVA Medical School
Regulatory T cell depletion unleashes an IFNγ+ γδ T cell response in the tumour microenvironment
André Santos, iMMJLA – Instituto de Medicina Molecular João Lobo Antunes
Radiotherapy Effect on Rectal Cancer Secretome
Miguel Ribeiro, i3S
Mutant KRAS elicits an intestinal-spleen immunoregulatory crosstalk during intestinal tumorigenesis
Sérgia Velho, i3S
10.55 – 11.00 Sponsor Talk – Novogene
11.00-11.30 Coffee Break & Poster Session
11.30-12.15 The role of macrophage ontogeny and metabolism in the lung
Adam Byrne, Imperial College London, UK
12.15-12.45 Selected Oral Presentations
The role of pDC and ER stress in systemic sclerosis-associated fibrosis
Beatriz Ferreira, iBiMED/CICECO, University of Aveiro
Bridging Fat and Tumour Development – Contributions from the peritumoural adipose tissue.
Miguel Mendes-Ferreira, i3S
Pluronic L121®-PEI and Hyaluronic Acid: a potential nanosystem to target CD44 receptor in Oral Cancer
Cátia Domingues, Universidade de Coimbra
12.45-13.15 Speed talks
Unveiling common molecular pathways linked to ILDs with progressive fibrosing phenotype
Rita Santos, i3S
Dissecting the crosstalk between plasmacytoid Dendritic Cells and fibroblasts
Inês Silva, Universidade de Aveiro
Investigating the role of IL-17 γδ T cells in peripheral nerve regeneration
Vladimir Ghilas, iMMJLA – Instituto de Medicina Molecular João Lobo Antunes
A micro approach for a macroproblem: Pexiganan A-grafted microspheres to clear H. pylori infection
Diana R. Fonseca, i3S/INEB, FEUP
LAMP-2 in thymic epithelial cells shapes the selection of CD4 T cells
Laura G. Sousa, i3S/IBMC, ICBAS
Identification of fibroblast progenitors in the developing thymus
Ruben Pinheiro, i3S/IBMC, ICBAS
13.15 – 13.20 Sponsor Talk – Lusopalex
13.20-14.25 Lunch & Poster Session
14.25 – 14.30 Sponsor Talk – Enzifarma
14.30-15.15 Cell metabolic reprogramming during organ regeneration
António Jacinto, NOVA Medical School | Faculdade de Ciências Médicas (NMS|FCM), Portugal
15.15-15.55 Selected Oral Presentations
Chitosan/poly(γ-glutamic acid) nanoparticles and IFN-γ: a winning combination to fight breast cancer
Flávia Castro, i3S/INEB
Polymeric nanoparticles as novel immunomodulatory chemotherapy to selectively target CEA-expressing colorectal cancer cells
Maria José Silveira, i3S/INEB
Immunomodulation of macrophage phenotype using ibuprofen-loaded poly (lactic-co-glycolic acid) nanoparticles to promote cartilage repair
Cristiana Couto, i3S/INEB
TLR-loaded-nanomedicines to reprogram Tumor-Associated Macrophages
Fernando Torres-Andón, University Santiago Compostela, Spain
15.55-16.15 Speed talks
Goodbye flat biology: Development of a 3D rectal cancer spheroid
Diogo Estevão, i3S
The role of the extracellular matrix on cancer stemness and immunogenicity
Ana Patricia Cardoso, i3S
Mimicking 3D tumor-immune interactions to unveil triple-negative breast cancer radioresistance
Flávia Castro, i3S/INEB
Dissecting the role of adipose tissue at the Tumor Microenvironment of Hodgkin Lymphoma disease
Andreia Matos, i3S, ICBAS, FMUL
The impact of inflammation on EV-mediated communication between Dendritic Cells and Mesenchymal Stem/Stromal Cells
Filipe Nogueira, i3S/INEB and ICBAS
16.15 – 16.20 Sponsor Talk : Alfagene
16.20-16.50 Coffee Break & Poster Session
16.50-17.50 Round Table: Fibrosis in cancer and regeneration
Moderator: Margarida Saraiva
Panel: Manuel Sobrinho Simões, Adam Byrne, Olivier de Wever, António Jacinto, Hélder Novais-Bastos
17.50-18.00 Closing Session and Awards
